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. Author manuscript; available in PMC: 2018 Jun 14.
Published in final edited form as: Neuroscience. 2017 Apr 10;353:76–86. doi: 10.1016/j.neuroscience.2017.04.001

Figure 3.

Figure 3

Distribution of TRPA1 and TRPM8 channels in cold-, menthol-and AITC-sensitive adult mouse DRG neurons. The experimental protocol is similar to the protocol outlined in the Figure 1 legend, with a few exceptions described below. Me is an abbreviation for 400 μM Menthol. (A) The TRPA1 antagonist HC-030031 (30 μM) selectively and completely blocked responses to cold, menthol, and AITC in 96.9% ± 0.7% of AITC-sensitive neurons (n=422). The black horizontal bars indicate when HC-030031 was present in the bath solution. (B) The TRPM8 antagonist M8-B (1 μM) selectively and completely blocked responses to cold and menthol in 95.0% ± 2.9% of menthol-sensitive and AITC-insensitive neurons (n=40). The open horizontal bars indicate when M8-B was present in the bath solution.