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. Author manuscript; available in PMC: 2018 Jun 14.
Published in final edited form as: Neuroscience. 2017 Apr 10;353:76–86. doi: 10.1016/j.neuroscience.2017.04.001

Figure 4.

Figure 4

Percentages of lumbar DRG neurons from wild-type mice at different ages that responded to menthol or AITC. At postnatal day 3 or 4 (P3-4), a very low percentage of neurons responded to AITC and nearly all of the menthol-sensitive neurons were insensitive to AITC. The menthol responsive and AITC non-responsive (M+A−) neurons, as a percentage of the neuronal cell population, remained relatively constant across different ages of mice. However, the AITC-sensitive neurons increased dramatically as a percentage of the neuronal cell population during postnatal development. Accordingly, the menthol-sensitive neurons that were also AITC sensitive (M+A+ neurons) increased as a percentage of the neuronal cell population during postnatal development. The legend shown above the stacked bar graphs for menthol-sensitive neurons only applies to the menthol-sensitive neurons. For each age of mice, at least 6 experimental trials were conducted, using at least 3 independently prepared cell cultures from different mice. Total number of neurons scored for each age category was 1412 for P3-4, 1385 for P13-14, and 1465 for P45-55. Error bars are +/− SEM.