Table 1.
Studies of carbapenem-resistant Klebsiella pneumoniae in solid organ transplant recipients.
Reference | Geographic Location | Incidence of Post-Transplant CRE Infection | Median Time from Transplant to CRE Infection | Type of Infectiona | Mortality Rate |
---|---|---|---|---|---|
Heart Transplants | |||||
20 | Brazil | 16.7% (2/12) | 90 days | Bacteremia: 50% Pneumonia: 50% | 50% (30-day) |
Lung Transplants | |||||
21b | Pittsburgh | 0.4% (2/546) | 218 days | Bacteremia: 100% | 0% (30-day) |
22 | Israel | 5.9% (8/136) | 27 days | Pneumonia: 38% UTI: 25% Bacteremia: 25% | 88% (overall) |
Liver Transplants | |||||
20 | Brazil | 12.9% (4/31) | 16 days | Bacteremia: 100% Pneumonia: 25% | 25% (30-day) |
21b | Pittsburgh | 1.3% (8/610) | 24 days | Bacteremia: 100% Pneumonia: 50% | 25% (30-day) |
23 | New York City | 8% (14/175) | 12 days | Bacteremia: 86% Peritonitis: 79% | 71% (overall)50% (30-day) |
31b | Greece | NR (17 cases) | 13 days | Bacteremia: 100% | 82% (ICU mortality) |
24 | New York City | 6.6% (20/304) | 11 days | SSI/intra-abdominal: 65% Bacteremia: 55% | 45% (overall) |
95 | Italy | 8.4% (20/237) | 42 days | Bacteremia: 90% Pneumonia: 30% | 45% (180-day) |
Kidney Transplants | |||||
25 | Brazil | 1.9% (21/1101) | 49 days | SSI: 48% Bacteremia: 39% | 42% (30-day) |
20 | Brazil | 26.3% (5/19) | 17 days | UTI: 60% Bacteremia: 60% | 60% (30-day) |
26 | Argentina | 13.3% (6/45) | 36 days | UTI: 83% Bacteremia: 17% | 33% (overall) |
27c | New York City | 1.1% (20/1852) | 47 days | Bacteriuria: 100% | 30% (overall) |
28 | New York City | 2.5% (13/522) | 185 days | UTI: 69% Bacteremia: 38% | 46% (overall) |
30 | Italy | NR (8 episodes) | NR | UTI: 100% Bacteremia: 100% | 0% (30-day) |
Intestinal Transplants | |||||
21b | Pittsburgh | 5.4% (6/112) | 209 days | Bacteremia: 100% | 33% (30-day) |
Notes. Abbreviations: CRE, carbapenem-resistant Enterobacteriaceae; UTI: urinary tract infection; NR, not reported; ICU, intensive care unit; SSI, surgical site infection
The 2 most common sites of infection are listed
The study evaluated episodes of CRE bacteremia only
The study evaluated episodes of CRE bacteriuria only