Figure 2.

Mechanism by which G6PD drives adipose tissue inflammation and systemic insulin resistance in obesity. Obese adipose tissue manifests in oxidative stress and secretion of pro-inflammatory cytokines in response to metabolic stresses, which is associated with G6PD activation. In obesity, G6PD expression increases and stimulates accumulation of oxidative stress by inducing ROS generation. Increased ROS activates transcriptional factors involved in the expression of pro-inflammatory cytokines. In turn, adipose tissue inflammation elevates and leads to systemic insulin resistance in obesity.