Table 2.
Odds ratio (OR) estimates for Hirschsprung’s Disease from logistic regression models, crude and adjusted OR with 95% confidence interval (CI) for occurrence of Hirschsprung’s Disease based on all live births in the period of 1 january 1996 until 12 March 2016
| SSRI prescriptions redeemed a minimum of one time | No prescriptions for SSRIs | Crude OR (95%CI) | Adjusted ORa (95%CI) | |
|---|---|---|---|---|
| Child born with Hirschsprung’s Disease | 16/19.807 (0.08%) | 584/1.236.510 (0.05%) | 1.71 (1.04–2.81) | 1,76 (1.07–2.92) |
| SSRI prescriptions redeemed one time only | No prescriptions for SSRIs | Crude OR (95%CI) | Adjusted ORa (95%CI) | |
| Child born with Hirschsprung’s Disease | 7/11.351 (0.06%) | 584/1.236.510 (0.05%) | 1.31 (0.62–2.75) | 1.33 (0.63–2.83) |
| SSRI prescriptions redeemed a minimum of two times | No prescriptions for SSRIs | Crude OR (95%CI) | Adjusted ORa (95%CI) | |
| Child born with Hirschsprung’s Disease | 9/8.456 (0.11%) | 584/1.236.510 (0.05%) | 2.25 (1,17–4.36) | 2.34 (1.21–4.55) |
aAdjusted for maternal age (≤19, 20–24, 25–29, 30–34, ≥35), maternal smoking (yes/no), sex, of child (male/female), parity (1/<1), calendar year of birth (1996–2001, 2002–2007, 2008–2011, 2012–2016)