Table 3.
Odds ratio (OR) estimates for Hirschsprung’s Disease from logistic regression models, crude and adjusted OR with 95% confidence interval (CI) for occurrence of Hirschsprung’s Disease based on all live births in the period of 1 january 1996 until 12 March 2016. All women with prescriptions 3 months prior to time of conception of antiepileptic, antidiabetic, antipsychotics, anxiolytic and tricyclic antidepressants are excluded from the population
| SSRI prescriptions redeemed a minimum of one time | No prescriptions for SSRIs | Crude OR (95%CI) | Adjusted ORa (95%CI) | |
|---|---|---|---|---|
| Child born with Hirschsprung’s Disease | 13/16.395 (0.08%) | 561/1.207.989 (0.05%) | 1.71 (0.99–2.96) | 1.76 (1.01–3.07) |
| SSRI prescriptions redeemed one time only | No prescriptions for SSRIs | Crude OR (95%CI) | Adjusted ORa (95%CI) | |
| Child born with Hirschsprung’s Disease | 6/9.663 (0.06%) | 561/1.207.989 (0.05%) | 1.34 (0.60–3.00) | 1.38 (0.61–3.09) |
| SSRI prescriptions redeemed a minimum of two times | No prescriptions for SSRIs | Crude OR (95%CI) | Adjusted ORa (95%CI) | |
| Child born with Hirschsprung’s Disease | 7/6.732 (0.10%) | 561/1.207.989 (0.05%) | 2.24 (1.06–4.72) | 2.32 (1.10–4.90) |
aAdjusted for maternal age (≤19, 20–24, 25–29, 30–34, ≥35), maternal smoking (yes/no), sex, of child (male/female), parity (1/<1), calendar year of birth (1996–2001, 2002–2007, 2008–2011, 2012–2016)