Table 2.
FDOPA uptake, MP binding in Study 1: Group comparisons by age
| Age group | HC (mean, SE, n) | LRRK2-U (mean, SE, n) | LRRK2-PD (mean, SE, n) | sPD (mean, SE, n) | ANOVA |
|---|---|---|---|---|---|
| FDOPA Caudate | |||||
| <=50 | 1·12 (0·22) n=8 |
1·04 (0·22) n=11 |
0·93 (0·22) n=1 |
0·84 (0·22) n=7 |
F(2,23) =12·38; p = 0·0002 HC = LRRK2-U > sPD# |
| 51–60 | 1·15 (0·23) n=6 |
1·08 (0·23) n=10 |
0·82 (0·23) n=2 |
0·77 (0·23) n=15 |
F(2,28) = 34·99; p < 0·0001 HC = LRRK2-U > sPD# |
| 61–70 | 1·08 (0·32) n=8 |
1·18 (0·32) n=3 |
0·7 (0·32) n=5 | 0·68 (0·32) n=21 |
F(3,33) = 18·12; p < 0·0001 HC = LRRK2-U > LRRK2-PD = sPD |
| >70 | 1·24 (0·3) n=9 | 1·06 (0·3) n=2 |
0·86 (0·3) n=5 | 0·76 (0·3) n=16 |
F(2,27) = 28·98; p < 0·0001 HC > LRRK2-PD = sPD* |
| FDOPA Putamen | |||||
| <=50 | 0·95 (0·26) n=8 |
0·9 (0·26) n=11 |
0·52 (0·26) n=1 |
0·45 (0·26) n=7 |
F(2,23) = 30·79; p < 0·0001 HC = LRRK2-U > sPD# |
| 51–60 | 1·01 (0·21) n=6 |
0·92 (0·21) n=10 |
0·48 (0·21) n=2 |
0·4 (0·21) n=15 |
F(2,28) = 109·23; p < 0·0001 HC = LRRK2-U > sPD# |
| 61–70 | 0·94 (0·28) n=8 |
0·98 (0·28) n=3 |
0·37 (0·28) n=5 |
0·35 (0·28) n=21 |
F(3,33) = 43·63; p < 0·0001 HC = LRRK2-U > LRRK2-PD = sPD |
| >70 | 1·02 (0·3) n=9 | 0·76 (0·3) n=2 |
0·53 (0·3) n=5 | 0·37 (0·3) n=16 |
F(2,27) = 52·46; p < 0·0001 HC > LRRK2-PD > sPD* |
| MP Caudate | |||||
| <=50 | 1·75 (0·47) n=7 |
1·38 (0·47) n=11 |
0·74 (0·47) n=1 |
0·86 (0·47) n=8 |
F(2,23) = 26·93; p < 0·0001 HC > LRRK2-U > sPD# |
| 51–60 | 1·38 (0·42) n=6 |
1·19 (0·42) n=11 |
0·55 (0·42) n=1 |
0·63 (0·42) n=16 |
F(2,30) = 36·72; p < 0·0001 HC = LRRK2-U > sPD# |
| 61–70 | 1·25 (0·43) n=8 |
1·06 (0·43) n=3 |
0·45 (0·43) n=4 |
0·52 (0·43) n=21 |
F(3,32) = 25·06; p < 0·0001 HC = LRRK2-U > LRRK2-PD = sPD |
| >70 | 1·16 (0·42) n=9 |
0·82 (0·42) n=2 |
0·66 (0·42) n=5 |
0·52 (0·42) n=18 |
F(2,29) = 26·31; p < 0·0001 HC > LRRK2-PD = sPD* |
| MP Putamen | |||||
| <=50 | 1·51 (0·44) n=7 |
1·18 (0·44) n=11 |
0·41 (0·44) n=1 |
0·44 (0·44) n=8 |
F(2,23) = 44·86; p < 0·0001 HC > LRRK2-U > sPD# |
| 51–60 | 1·23 (0·33) n=6 |
1·03 (0·33) n=11 |
0·3 (0·33) n=1 | 0·35 (0·33) n=16 |
F(2,30) = 82·82; p < 0·0001 HC > LRRK2-U > sPD# |
| 61–70 | 1·08 (0·27) n=8 |
0·83 (0·27) n=3 |
0·28 (0·27) n=4 |
0·31 (0·27) n=21 |
F(3,32) = 68·36; p < 0·0001 HC > LRRK2-U > LRRK2-PD= sPD |
| >70 | 0·96 (0·33) n=9 |
0·5 (0·33) n=2 |
0·41 (0·33) n=5 |
0·31 (0·33) n=18 |
F(2,29) = 44·84; p < 0·0001 HC > LRRK2-PD = sPD* |
HC= healthy control; LRRK2-U= unaffected mutation carrier; LRRK2-PD= affected mutation carrier; sPD = sporadic PD;
*
LRRK2-U excluded; #LRRK2-PD excluded.