Table 1. Summary of Associations With Trabecular vBMD.

Locus	Position (build 36)	SNP	Nearest gene(s) (distance in kb)a	A1/A2	A1 frequency	Beta for A1	SE	Heterogeneity I2	p
									Discovery (n = 12,287)	Combined (n = 15,275)b
Combined p < 5 × 10−8 for trabecular vBMD
1p36.12	22444772	rs12755933	WNT4 (103)	C/G	0.27	−0.084	0.013	0	2.66 ×10−10	9.80 ×10−11
1p36.12	22554953	rs12742784	ZBTB40 (96)	C/T	0.21	0.094	0.015	0	1.18 × 10−10	1.05 ×10−10
1q43	238659259	rs9661787	FMN2 (0)-GREM2 (60)	C/G	0.81	−0.098	0.015	0	1.26 × 10−10	1.29 ×10−11
5p13	36516441	rs2468531	SLC1A3 (126)-RANBP3L (179)	G/C	0.03	0.221	0.037	0	1.47 × 10−9	1.91 × 10−8
8q24	120045437	rs1485303	TNFRSF11B (12)	A/G	0.44	−0.057	0.012	14.6	7.35 × 10−7	4.63 × 10−9
13q14	41862203	rs17457561	AKAP11 (67) (TNFSF11 [700])	A/G	0.25	−0.095	0.014	0	1.95 × 10−12	1.12 × 10−11
Combined 5 × 10−8 ≤ p < 5 × 10−6 for trabecular vBMD
2p21	54735125	rs2941584	SPTBN1 (0)	C/T	0.32	−0.060	0.012	33.5	1.26 × 10−6	1.29 ×10−7
6q25	151897286	rs10872673	C6orf97 (40)	G/T	0.60	0.065	0.012	0	5.92 × 10−8	8.22 ×10−7
12p13.3	2378832	rs7301013	CACNA1C(298)	A/G	0.83	−0.076	0.016	39.4	1.45 × 10−6	4.90 × 10−7
12p12.1	28183168	rs12813778	CCDC91 (118)-PTHLH (167)	A/G	0.23	−0.068	0.014	32.9	1.16 × 10−6	2.35 ×10−6
12q21.3	88861177	rs4842697	ATP2B1 (287)	G/T	0.57	−0.057	0.012	22.4	9.09 × 10−7	2.60 × 10−6
16p13.3	315783	rs9921222	AXIN1 (27)	C/T	0.47	−0.059	0.012	0	6.09 × 10−7	4.90 × 10−7

vBMD = volumetric BMD.

^aLocus zoom plots are in Supplemental Fig. 3.

^bObservations were added by new genotyping in AGES (n = 2021) and/or by in silico replication in DHS (n = 967). The SNP association was considered to be replicated if the addition of the replication sample to the meta-analysis did not result in a p >5 × 10⁻⁸.