|
Recommendation for
Pentoxifylline |
|
COR |
LOE |
Recommendation |
|
III: No Benefit |
B-R |
Pentoxifylline is not effective
for treatment of claudication.200,203
|
|
See Online Data Supplement
26. |
In a Cochrane review of 24 studies with
3377 participants, there was large variability in study design and
results between individual studies, and therefore the
review's effectiveness was unclear.203 Pentoxifylline was shown to
be generally well tolerated.203 In a multicenter RCT of pentoxifylline,
cilostazol, or placebo for patients with moderate-to-severe
claudication, there was no difference between pentoxifylline and
placebo in the primary endpoint of maximal walking
distance.200 Therefore, pentoxifylline is not recommended
as treatment for claudication. |
|