2016 AHA/ACC Guideline on the Management of Patients With Lower Extremity Peripheral Artery Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines

. Author manuscript; available in PMC: 2017 Sep 21.

Published in final edited form as: Circulation. 2016 Nov 13;135(12):e726–e779. doi: 10.1161/CIR.0000000000000471


Recommendation for Influenza Vaccination

COR	LOE	Recommendation

I	C-EO	Patients with PAD should have an annual influenza vaccination.

See Online Data Supplements 30 and 31.		Observational studies have demonstrated reduced cardiovascular event rates among patients with cardiovascular disease who have received an influenza vaccination.³⁰ Two RCTs that enrolled patients with CAD demonstrated a benefit of an influenza vaccination on the prevention of cardiovascular events, particularly coronary ischemic events.^208,209 Although these trials did not specifically enroll participants with PAD, a majority of patients with PAD also have CAD.³⁰ On the basis of this evidence, an annual influenza vaccination is recommended as a component of medical therapy for patients with PAD.