Recommendation for ALI Medical Therapy
COR	LOE	Recommendation
I	C-EO	In patients with ALI, systemic anticoagulation with heparin should be administered unless contraindicated.
N/A		Heparin (generally intravenous unfractionated heparin) is given to all patients acutely.35,364 This can stop thrombus propagation and may provide an anti-inflammatory effect that lessens the ischemia. Patients who have received heparin before the onset of ALI and have a decrease in platelet count may have heparin-induced thrombocytopenia.365,366 In this situation, a direct thrombin inhibitor is given, rather than heparin, if heparin-induced thrombocytopenia with thrombosis is suspected.