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Total diffusion flux (A) and permeability coefficient (B) of molecules through mouse Bruch's membrane plotted as a function of Rs. Molecules include cytosine (Rs < 1.0 nm), RNase A (Rs = 1.72 nm), albumin (Rs = 3.55 nm), and ferritin (Rs = 6.15 nm). Data points are given as mean ± SD, n ≥ 5 mice per genotype. +/+, Efemp1+/+; ki/ki, Efemp1ki/ki; −/−, Efemp1−/−.
