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. 2016 Oct 3;34(33):4030–4039. doi: 10.1200/JCO.2016.67.1222

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© 2016 by American Society of Clinical Oncology

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Fig A1. — Comparison of cellularity, isocitrate dehydrogenase 1 (IDH1; R132H) immunoreactivity, and 2-hydroxyglutarate (2HG) concentration (mM) among various grades of glioma. Cellularity was assessed from hematoxylin and eosin (HE) staining. All images are ×200 magnification. (A) Glioblastoma (secondary) shows multiple mitoses with dense cellularity and strong IDH1/R132H immunoreactivity. (B) Grade 3 oligodendroglioma (1p/19q codeleted) shows high cellularity and strong IDH1/R132H immunoreactivity. (C) Grade 3 astrocytoma and (D) grade 2 oligodendroglioma have moderate cellularity, whereas IDH1/R132H staining intensity was unchanged. (E) Grade 2 astrocytoma demonstrated low cellularity with equivalent IDH1/R132H staining intensity. 2HG concentration is correlated with cellularity.