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. 2016 Jan 12;17:4. doi: 10.1186/s12931-016-0320-0

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© Dong et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 9 — Effect of BMAL1 knockdown on TGF-β1-induced signaling transduction. a HPL1D cells in 6-well plates were transfected with siBMAL1 or siCtrl for 48 h and stimulated with TGF-β1 at 5 ng/ml for 30 min. The level of phosphorylated Smad3 was detected with phospho-specific antibodies. The total level of Smad3 was also investigated. b NHLFs in 6-well plates were transfected with siBMAL1 or siCtrl for 48 h and stimulated with TGF-β1 at 1 ng/ml for 18 h. The levels of phosphorylated and total Akt were detected with specific antibodies. * p < 0.05 vs. corresponding control siRNA groups stimulated with TGF-β1 (siCtrl-TGF-β1)