. 2008 Jan 14;1(2):85–88. doi: 10.1093/ndtplus/sfm048

Table 1.

Results of treatment with rituximab in adult patients with recurrent FSGS after renal transplantation

Study	Donor source	Immuno-suppression	Age at transplantation	Time to recurrence^a	Concurrent disease?	Plasma exchange?	Rituximab dose	Comments
Hristea [8]	LRD	Pred; Tac; MMF; Basiliximab	22 years	2 days	None	Yes, partial response	375 mg/m² once weekly; two doses	Complete remission; PE and rituximab were used concomitantly
Gossmann [10]	Post-mortal	Pred; Tac; MMF; ATG	48 years	40 days	None	Yes, no response	375 mg/m² once weekly; two doses	Complete remission after rituximab
Meyer [11]	LRD	Pred; Tac; MMF; Basiliximab	31 years	2 months	None	Yes, preemptive, partial response	375 mg/m² once weekly; three doses	Partial remission after rituximab
El-Firjani [13]	LRD	Pred; Tac; MMF; ATG	48 years	1 month	None	Yes, no response	375 mg/m^2; six doses in 8 weeks	No remission after rituximab
Kamar [9]	Post-mortal	Pred; CsA; MMF; Basiliximab	25 years	1 day	None	Yes, preemptive, partial response	375 mg/m² once weekly; two doses	Complete remission; however, PE and rituximab were used concomitantly; A relapse was also treated with rituximab and PE, proteinuria had already decreased significantly before rituximab treatment
	Post-mortal	Pred; CsA; MMF; Basiliximab	46 years	1 day	None	Yes, no response	375 mg/m² once weekly; four doses	No remission after rituximab
Yabu [12]	Post-mortal	Pred; Tac; MMF	41 years	3 days	None	Yes, partial response	1000 mg fortnightly; two doses	No remission after rituximab
	LRD	Pred; Tac; MMF; ATG	43 years	2 months	None	Yes, >50% decrease in proteinuria, no remission	375 mg/m² once weekly; four doses	No remission after rituximab
	LRD	Total lymphoid irradiation; ATG; CsA; MMF; pred	41 years	<14 days	None	Yes, no response	375 mg/m² once weekly; six doses	No remission after rituximab
	LRD	JAK3 inhibitor; MMF; Pred	47 years	1 month	None	Yes, partial response	375 mg/m² once weekly; six doses	No remission after rituximab

^aExact time to recurrence not available.

Definitions: complete remission = proteinuria <0.2 g/24 h; partial remission/response = proteinuria between 0.2 g/24 h and 2.0 g/24 h.

LRD = living related donor; ATG = anti-thymocyte globulin; Aza = azathioprine; CsA = Cyclosporine; MMF = mycophenolate mofetil; Pred = prednisone; Tac = tacrolimus; PE = plasma exchange.