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Schematic diagram showing known and potential relationship between obesity-linked type 2 diabetes and cancer. (a) The relationship between obesity and type 2 diabetes is linear, which progress from obesity-related adipose tissue abnormalities to insulin resistance, β-cell insufficiency, and eventually type 2 diabetes. (b) Preexisting immune dysregulation may play a role in obesity-linked cancer development. (A color version of this figure is available in the online journal.)
