Skip to main content
. 2017 Apr 21;242(11):1142–1149. doi: 10.1177/1535370217705865

Figure 2.

Figure 2

Role of PRC1 in canonical Wnt signaling in HCC cells. As a transcriptional target of Wnt signaling in HCC cells, PRC1 expression is activated by the β-catenin/TCF complex. Upon Wnt signaling activation, PRC1 is transferred to MTs and the membrane cortex, which helps to sequester the destruction complex of Axin, APC, GSK3, CK1 and β-catenin at the MTs and the membrane, leading to Wnt signalosome activation and stabilization of β-catenin in HCC cells. (A color version of this figure is available in the online journal.)