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. 2017 Jun 20;12(6):e0177432. doi: 10.1371/journal.pone.0177432

Fig 5. Proposed pathway for mtl-1 transcriptional activation in C. elegans.

Fig 5

(A) In times of no stress, ATF-7 is bound to the CRE-like sequence located in the promoter region of mtl-1 thus blocking transcriptional activation. Additionally, the AKT-1/-2 complex is inhibiting the ability of PMK-1 to translocate to the nucleus. (B) Upon the introduction of stress PDK-1 is phosphorylated which leads to the phosphorylation of the AKT-1/-2 complex. This activation causes the release and subsequent activation of PMK-1 allowing it to translocate to the nucleus. PMK-1 phosphorylated ATF-7 releasing it from the DNA which allows ELT-2 to bind the GATA sequence initiating transcription of mtl-1.