Table 1. Establishing the ex vivo mouse heart model of AHF (lean male mice).
| Parameters | Baseline vs. CAHF |
CAHF Phase (% of Baseline) |
CAHF vs. RAHF |
RAHF Phase (% of Baseline) |
Baseline vs. RAHF |
|---|---|---|---|---|---|
| Heart rate (%) |
ns |
274.70 ± 81.42 | ns |
118.90 ± 12.72 | ns |
| LVDevP (%) |
*** |
6.40 ± 4.12 | ns |
15.23 ± 3.31 | ### |
| LVEDP (%) |
** |
65.06 ± 6.89 | *** |
120.30 ± 6.60 | ns |
| LVESP (%) |
*** |
46.47 ± 5.75 | *** |
86.11 ± 1.61 | # |
Data from the CAHF and RAHF phases were normalized to baseline and thus the CAHF and RAHF phases data are expressed as a percentage of baseline (n = 6). Data represent the last ten minutes of each phase. Significance is expressed as **p<0.01; ***p<0.001 vs. CAHF and #p<0.05; ###p<0.001 vs. RAHF. LVDevP: left ventricular developed pressure; LVEDP: left ventricular end diastolic pressure; LVESP: left ventricular end systolic pressure; CAHF: critical acute heart failure; RAHF: recovery acute heart failure; ns: not significant.