Table 13. AHF ex vivo model–underlying features.

Baseline stabilization	CAHF	RAHF
Simulated metabolism
Normal glucose	Low glucose	Normal glucose
No FAs	FAs	FAs
(Normal fuel)	(Push towards FAO)	(Choice in fuel)
Induced functional parameters
Normal pressure	Low pressure	Normal pressure
Normal perfusion	Low perfusion	Normal perfusion
Paced	Unpaced	Paced
Expected function under simulated conditions
Normal	Critically low	Increased function (recovery)
Expected function with TMZ treatment
	Restore equilibrium back to glucose utilization	Favors the equilibrium towards glucose utilization

FAs: fatty acids; FAO: Fatty acid β-oxidation