Table 1. Description of the population analyzed from the Enroll-HD database.
| Non-HD individuals (n = 1384) | HD patients (n = 5616) | |||||||
|---|---|---|---|---|---|---|---|---|
| No metformin (n = 1282) (No diabetes) | Metformin (n = 102) (Type 2 diabetes) | No metformin (n = 5456) (No diabetes) | Metformin (n = 160) (Type 2 diabetes) | |||||
| Genotype negative (n = 644) | Family control (n = 638) | Genotype Negative (n = 37) | Family control (n = 65) | Pre- Manifest (n = 1232) | Motor- Manifest (n = 4224) | Pre- Manifest (n = 39) | Motor- Manifest (n = 121) | |
| Age | 45.6 (14.47) a 46 (34, 56) | 56.09 (11.72) 58 (49, 64.5) | 52.97 (12.92) 53 (44, 63) | 61.97 (10.38) 63 (55, 69) | 41.82 (11.9) 41 (33, 51) | 53.32 (12.56) 54 (45, 62) | 49.77 (13.05) 50 (38.5, 58) | 59.39 (10.92) 59 (52, 68) |
| Sex Female Male | 470 (73.0%) 174 (27.0%) | 395 (61.9%) 243 (38.1%) | 24 (64.9%) 13 (35.1%) | 23 (35.4%) 42 (64.6%) | 813 (66.0%) 419 (34.0%) | 2198 (52.0%) 2026 (48.0%) | 26 (66.7%) 13 (33.3%) | 58 (47.9%) 63 (52.1%) |
| Body Mass Index | 27.67 (6.44) 26.5 (23.4, 30.8) | 28.88 (6.16) 28 (24.7, 31.6) | 36.05 (8.09) 34.6 (31.6, 39) | 34.04 (6.39) 32.7 (29.62, 37.78) | 26.8 (5.6) 25.8 (22.75, 29.8) | 25.04 (5.1) 24.3 (21.6, 27.58) | 33.06 (6.54) 32.4 (28.4, 36.5) | 29.5 (6.05) 28.85 (25.1, 32) |
| ISCED b | 4.03 (1.14) 4 (3, 5) | 3.89 (1.19) 4 (3, 5) | 3.27 (1.41) 3 (3, 4) | 3.75 (1.24) 4 (3, 5) | 3.91 (1.13) 4 (3, 5) | 3.37 (1.23) 3 (2, 4) | 3.85 (1.11) 4 (3, 5) | 3.31 (1.35) 3 (2, 5) |
| CAG repeats | 20.22 (3.66) 19 (18, 22) | 20.05 (3.41) 19 (17, 22) | 20.65 (3.03) 21 (18, 22) | 20.15 (3.83) 19 (17, 22) | 42.29 (2.72) 42 (41, 43) | 44.03 (3.95) 43 (42, 45) | 40.87 (2.12) 41 (39.5, 42) | 42.34 (2.33) 42 (41, 43) |
a Data are presented as mean (SD) and median (1st, 3rd quartile).
b International Standard Classification of Education promoted by UNESCO to standardise.