Table 3. Risks of dementia and AD after a cancer diagnosis among ACT study participants.
This table shows follow-up time, dementia and AD incidence, and crude and unadjusted risks of dementia and AD for prevalent and incident cancers. Abbreviations include: ACT (Adult Changes in Thought); AD (Alzheimer’s disease); CI (confidence interval); and HR (hazard ratio).
| Dementia | follow-up time(person-years) | # events | Incidence per 1000 person years | 95% CI | Crude HR1 | 95% CI | Adjusted HR2 | 95%CI |
|---|---|---|---|---|---|---|---|---|
| No cancer | 26,735 | 839 | 31.4 | 29.3, 33.6 | 1 | 1 | ||
| Prevalent cancer | 4,872 | 154 | 31.6 | 27.0, 37.0 | 0.93 | 0.78, 1.10 | 0.92 | 0.76, 1.11 |
| Incident cancer | 2,874 | 98 | 34.1 | 28.0, 41.6 | 0.82 | 0.66, 1.01 | 0.82 | 0.64, 1.04 |
| Possible/Probable AD | ||||||||
| No cancer | 26,735 | 678 | 25.4 | 23.5, 27.3 | 1 | 1 | ||
| Prevalent cancer | 4,872 | 126 | 25.8 | 21.7, 30.8 | 0.93 | 0.77, 1.13 | 0.95 | 0.77, 1.17 |
| Incident cancer | 2,874 | 73 | 25.4 | 20.2, 31.9 | 0.73 | 0.58, 0.94 | 0.73 | 0.55, 0.96 |
1Crude HR uses age as the time scale
2Additionally adjusted for age at ACT study entry, ACT cohort, gender, education, diabetes, hypertension, heart disease, stroke, smoking status, low self-rated health, regular exercise, and body mass index