Table 4. Sensitivity analyses showing odds ratio (OR) for confirmed NEC in infants exposed to feeding advancements and PRBC transfusion 24 and 72 hours prior to NEC onset.
Hazard Period | A | B | C | D | OR (95% CI) a | |
---|---|---|---|---|---|---|
Feed fortification | 24 hours | 2 | 7 | 6 | 17 | 1.17 (0.39, 3.47) |
72 hours | 6 | 12 | 8 | 6 | 1.50 (0.61, 3.67) | |
Feeding volume increase | 24 hours | 9 | 7 | 13 | 25 | 0.54 (0.21, 1.35) |
72 hours | 32 | 8 | 11 | 3 | 0.73 (0.29, 1.81) | |
PRBC transfusion | 24 hours | 0 | 7 | 6 | 25 | 1.17 (0.39, 3.47) |
72 hours | 3 | 12 | 5 | 18 | 2.40 (0.85, 6.81) |
Abbreviations: NEC, necrotizing enterocolitis; PRBC, packed red blood cells
A: Number of concordant pairs exposed in both hazard and control period (n11)
B: Number of discordant pairs exposed in hazard period, unexposed in control period (n10)
C: Number of discordant pairs unexposed in hazard period, exposed in control period (n01)
D: Number of concordant pairs unexposed in both hazard and control period (n00)
a OR defined as B/C or n10/ n01