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. Author manuscript; available in PMC: 2017 Jun 20.
Published in final edited form as: J Am Coll Cardiol. 2016 Sep 27;68(13):1435–1448. doi: 10.1016/j.jacc.2016.07.729

CENTRAL ILLUSTRATION. Gene-Related Cardiac Conditions.

CENTRAL ILLUSTRATION

In this study, a number of gene-containing loci were identified that influence a variety of abnormalities in the dysfunctional heart, myocardium, and cardiac myocytes. Analyzing the QRS genome-wide association study results using the DEPICT (Data-Driven Expression-Prioritized Integration for Complex Traits) tool identified 43 meta-gene sets (Figure 5B); 1 of these is the “dilated heart left ventricle,” of which the effects of the individual gene sets are visualized in the illustration. The correlation substructure and the p values of this gene set are also displayed in Online Figure 12.