Fig. 9.

Heatmap of cellular behavior upon RIOK1 knockdown and MTAP status analysis. (a) Scoring determined based on densitometry measurements as follows: strongly decreased: reduction in expression ≥ 40%; decreased: reduction in expression ≥ 20%; increased: augmented expression ≥ 50%; n.d. not determined. (b) Western blot analysis of MTAP expression in different cell lines of colon-, breast- and und lung cancer (N = 1). (c) RIOK1 knockdown does not influence MTAP expression in NCI-H1299 and MB-MB-231 cells (N = 1).