Table 2. Effect of F991 on leukocyte accumulation in the lung air spaces 24 h after DNBS challenge of vehicle or DNFB-sensitized BALB/c mice.
Leukocytes in BAL (cells/lung × 104)
|
|||||
---|---|---|---|---|---|
n | DNFB | Total cells | PMN | MONO | |
PBS | 6 | – | 2.20 (1.22–3.15) | 0.03 (0.01–0.05) | 2.16 (1.14–3.10) |
6 | + | 2.19 (1.35–2.71) | 0.13* (0.09–0.24) | 2.06 (1.24–2.60) | |
F991 | 5 | – | 3.10 (2.01–3.45) | 0.06 (0.03–0.12) | 2.89 (2.49–3.41) |
6 | + | 2.70 (1.95–3.15) | 0.05 (0.03–0.08) | 2.64 (1.90–3.07) |
Leukocytes (PMN, polymorphonuclear cells; MONO, mononuclear cells) were determined in BAL fluid of vehicle (–) or DNFB-sensitized (+) mice. Results are expressed as median (minimum – maximum). Significant differences between vehicle- and DNFB-sensitized groups are indicated (*, P < 0.05 vs. vehicle-sensitized mice).