Fig. 2.
Motor and visual dysfunctions in ZIKV-infected mice.
(a) Representative paw print images acquired by Catwalk system. LF: Left front; RF: Right front; LH: Left hind; RH: Right hind. (b) Schematic diagrams of six step patterns. (c and d) Percentage of different step patterns and support time spent from mock- and non-paralyzed ZIKA-infected mice. Zero: support without paws; Single: support with one paw; Diagonal: support with two diagonal paws; Girdle: support with both front paws or hind paws simultaneously; Lateral: support with two paws at the same side of the body; Three: support with three paws; Four: support with four paws (nmock = 10 mice, nZIKV = 9 mice). (e–g) The ratio of stride length (e), stride width (f) and max contact areas (g) from print to body weight of mice (nmock = 10 mice, nZIKV = 9 mice). (h) Latency to fall off the rota-rod of mock- and non-paralyzed ZIKA-infected mice at P40. (i) The traces of mock- and ZIKV-infected mice in elevated plus maze. Solid line: close arm; dotted line: open arm. (j–l) The ratio of number of entries (j), distance traveled (k), and time spent (l) in close and open arms (nmock = 10 mice, nZIKV = 8 mice). All the data showed mean ± SEM, ***P < 0.001, **P < 0.01, *P < 0.05. Black circles represented raw data.