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Empagliflozin ameliorates diet-induced insulin resistance. (a) Fed blood glucose levels. (b, c) GTT and ITT. (d) Plasma insulin levels. (e) Ratio of plasma insulin to glucagon levels. (f) Representative insulin and glucagon-stained pancreas sections. Scale bars = 100 μm. (g) Islet numbers and sizes. Data are presented as means ± SEM, n = 7–9. *P < 0.05, **P < 0.01 vs. NC; #P < 0.05, ##P < 0.01 vs. HFD.
