Figure 3.

Kidney biopsy findings from patient II-9. (A) Light microscopy shows an increased mesangial cellularity and matrix, thickened glomerular basement membrane, and double-contour formation. (Hematoxylin and eosin stain, original magnification: ×400). (B) Light microscopy shows tubular epithelium vacuolar degeneration, defuse loss of the tubule brush border, and tubule dilatation. (Hematoxylin and eosin stain, original magnification: ×400). (C) Light microscopy shows capillary wall mesangial interposition and double-contour formation. (Periodic acid–Schiff stain, original magnification: ×400). (D) Electron microscopy shows a thickened glomerular basement membrane (black arrow) and expansion of the lamina rara interna (white arrow) (original magnification: ×10,000).