Table 2.

CNS Medication Standardized Daily Dose by Class and Overall by Group Status, Within 6 Days Prior To the Outcome

CNS Class and Overall SDD Variables	Controls (n=1468) Mean (sd) [IQR]	Cases (N=367) Mean (sd) [IQR]	P value*
Antidepressants (SSRIs or SNRIs or TCAs)	0.76 (1.34) [0.0–1.0]	1.07 (1.55) [0.0–2.0]	<0.001
Antiepileptics	0.18 (0.55) [0–0]	0.24 (0.72) [0–0]	0.05
Antipsychotics	0.47 (2.38) [0–0]	0.83 (2.95) [0–0]	0.02
Benzodiazepine receptor agonist hypnotics	0.08 (0.34) [0–0]	0.06 (0.32) [0–0]	0.37
Opioids receptor agonists	0.97 (2.56) [0–0]	0.88 (1.96) [0–0.65]	0.54
Overall CNS Medication Use	2.45 (4.01) [0–3.2]	3.07 (4.29) [0–4.3]	0.008
CNS SDD Use Categories, n (%)			<0.001
0	520 (35.4)	114 (31.1)
>0 – <3	537 (36.6)	102 (27.8)
3+	411 (28.0)	151 (41.1)

Abbreviations: CNS = central nervous system; IQR= inter quartile range (25th–75th percentile); SD= standard deviation; SNRI = serotonin norepinephrine reuptake inhibitor; SSRI = selective serotonin reuptake inhibitor; SDD=standardized daily dose; TCA = tricyclic antidepressant