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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: Leuk Lymphoma. 2017 Jan 31;58(9):2026–2039. doi: 10.1080/10428194.2017.1283032

Figure 1.

Figure 1

Potential mechanism of action of ABT-199 (venetoclax). Venetoclax binds to the BH3-binding groove of BCL-2 and displaces Bim and other BH3-only proteins that are normally sequestered by this pro-survival (anti-apoptotic) protein. These BH3-only proteins are thus freed to activate the apoptosis effectors, Bax and Bak. Bax/Bak activation then leads to their oligomerization and mitochondrial outer membrane permeabilization. This commits the cell to apoptosis through the mitochondrial pathway, which is triggered by the activation of caspases. Modified, with permission, from ref. [51].