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. 2017 Jun 20;7:3879. doi: 10.1038/s41598-017-04223-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The TIP60-deficient cells accumulated significantly more cells in S-phase than the TIP60-proficient cells in 10 μM cisplatin. (A) Cells were chronically treated with 5 μM or 10 μM cisplatin for 24 or 48 hours. Fractions of the S phase cells were determined by the flow cytometry. (B) Each value represents the mean ± standard deviation from two independent experiments. The significant difference between the control LacZ and the shTIP60 HONE6 cells was indicated, with a p-value < 0.05 (Student’s t-test).