Table 2.

Top 20 tandem-oriented hypermethylated downstream genes.

	downstream CpG-island	downstream gene	Downstream CpG island methylation (%)
			A549	H322	A427	mean LuCa	NLu1	NLu2	mean normal	methylation differences
1	chr2:201450526–201451027	AOX1	82	94	94	90	6	5	6	85
2	chr3:50377803–50378540	RASSF1A	93	91	91	92	7	8	8	84
3	chr14:24803678–24804353	ADCY4	90	93	92	92	12	7	10	82
4	chr17:40932329–40933299	WNK4	92	94	93	93	15	15	15	78
5	chr19:50193020–50194798	CPT1C	92	90	92	91	14	13	14	77
6	chr3:49314437–49314815	C3orf62	53	95	96	81	5	5	5	77
7	chr11:64066757–64068741	TEX40	81	79	85	82	12	11	12	70
8	chr17:72931729–72932601	OTOP30	78	90	88	86	19	16	17	68
9	chr11:66045211–66045708	CNIH2	28	97	86	70	3	4	3	67
10	chr1:36771830–36773009	SH3D21	37	93	92	74	8	8	8	66
11	chr1:21043832–21044771	KIF17	60	75	66	67	8	9	9	59
12	chr17:72855621–72858012	GRIN2C	35	48	93	59	8	8	8	51
13	chr17:6679205–6679710	FBXO39	23	88	87	66	20	14	17	49
14	chr12:7023261–7024089	ENO2	38	54	92	61	13	13	13	48
15	chr11:64509433–64513826	RASGRP2	21	69	59	49	6	6	6	43
16	chr17:46670522–46671458	PHPT1	23	51	72	49	7	6	6	43
17	chr2:74729399–74731166	LBX2	59	36	86	60	19	17	18	42
18	chr6:30881533–30882296	VARS2	23	58	67	49	10	9	10	40
19	chr11:62368454–62370491	MTA2	53	37	55	48	12	20	16	33
20	chr11:2907308–2907675	CDKN1C	51	38	51	47	17	15	16	31