Table 3.
Effects of dual and mono antiplatelet therapy on outcomes by DBP levels.
| Outcome | DBP mmHg | Clopidogrel-Aspirin Event rate (%) | Aspirin Event rate (%) | Crude | Adjusted | ||
|---|---|---|---|---|---|---|---|
| Hazard ratio (95% CI) | P value | Hazard ratio(95% CI) | P value* | ||||
| Stroke | ≥90 | 108 (8.0) | 182 (13.3) | 0.588 (0.463–0.746) | <0.001 | 0.597 (0.471–0.758) | <0.01 |
| <90 | 103 (8.3) | 121 (10.0) | 0.830 (0.638–1.080) | 0.161 | 0.819 (0.629–1.065) | 0.136 | |
| CVD | ≥90 | 110 (8.2) | 186 (13.6) | 0.585 (0.462–0.741) | <0.001 | 0.595 (0.470–0.753) | <0.001 |
| <90 | 105 (8.5) | 121 (10.0) | 0.846 (0.652–1.099) | 0.208 | 0.86 (0.643–1.085) | 0.178 | |
| Bleeding | ≥90 | 29 (2.2) | 20 (1.5) | 1.434 (0.811–2.535) | 0.215 | 1.408 (0.796–2.489) | 0.239 |
| <90 | 31 (2.5) | 21 (1.7) | 1.398 (0.801–2.443) | 0.239 | 1.426 (0.816–2.494) | 0.213 | |
*Adjusted for gender, age, body mass index, history of TIA or ischemic stroke, hypertension, hypercholesterolemia, diabetes mellitus, current or previous smoking, moderate to heavy drinking, qualifying event, antihypertensive drugs, lipid-lowering agent and antidiabetic agent.
Abbreviations: CVD = combined vascular events (ischemic stroke, hemorrhagic stroke, myocardial infarction, or vascular death); DBP = diastolic blood pressure.