Table 1. Lesion phenotype in T-bet^+/+Ldlr^-/- and T-bet^-/-Ldlr^-/- mice after 8 weeks of a high-fat/cholesterol diet.

Mouse genotype	Macrophages, % of intimal area	Smooth muscle cells, % of intimal area	CD4-positive cells (no. of lesional cells per section)	VCAM-1, % of intimal area	Class II MHC, % of intimal area
T-bet+/+Ldlr-/-	9.5 ± 2.2	1.0 ± 0.3*	1.3 ± 0.6	9.7 ± 1.2	4.1 ± 0.8
T-bet-/-Ldlr-/-	10.3 ± 2.1	0.3 ± 0.2*	1.7 ± 0.7	6.8 ± 1.3	3.3 ± 0.8

Values for macrophages, smooth muscle cells, CD4⁺ T cells, vascular cell adhesion molecule 1 (VCAM-1), and class II MHC-positive staining are expressed as mean ± SEM, determined by image analysis, as described in Methods. n = 12 (6 males and 6 females) for each group. *, P = 0.04.