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. 2017 Jun 20;7:3860. doi: 10.1038/s41598-017-04170-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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AAV-shRNA inhibits HBV replication and expression in HBV-persistent mice. Mice received AAV2-shRNA treatment, and serum and liver samples were collected at the indicated time points during a 6 month period. HBV DNA levels in serum (a) and liver tissues (b) were measured by qPCR, and HBV RNA levels were quantified by RT-qPCR (c). Serum HBsAg (d) and HBeAg (e) were measured by ELISA. P < 0.05: significant difference, Data represent the mean ± SD. HBV(+) mice, HBV-persistent mice with administration of PBS; HBV(−) mice, wild-type mice injected with PBS; AAV-scrambler, HBV-persistent mice treated with AAV2-scrambler, a vector carrying a scrambled shRNA sequence not targeted to the HBV genome; AAV-shRNA-1, HBV-persistent mice treated with an AAV2 vector carrying the single shRNA-1 against HBV; AAV-shRNA-1 + 3, HBV-persistent mice treated with an AAV2 vector carrying shRNA-1 and shRNA-3 against HBV; AAV-shRNA-TGF-β, HBV-persistent mice treated with AAV2-shRNA against TGF-β.