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. 2017 Jun 20;7:3914. doi: 10.1038/s41598-017-04305-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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rAAV vehicles drives gene expression in the medial entorhinal cortex (MEC). Low-magnification view of a horizontal section of mouse brain stained with hoechst ((A) vector; (C) P301L) and GFP autofluorescence showing a restriction of target protein expression in MEC and its projection fibers to the middle molecular layer (mml) of hippocampal dentate gyrus (DG) ((B) vector; (D) P301L, arrows point cell bodies) one month after transduction via rAAV delivery, while no GFP was observed in the granular layer (gl) of the dentate gyrus, which is outlined with a white dotted line (scale bar, 500 μm). The insets in (B,D) show the high magnification of MEC (scale bar, 50 μm). HT-7 was employed to detect human tau in the present study. The results showed a co-localization of HT-7 with GFP in the neuronal cell bodies and fibers of MEC (E–G), and the projection fibers to DG region (H–J). (scale bar in (A–D) 500 μm; in insets of (B,D) 50 μm; in E-J, 50 μm).