Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Jun 20;7:3914. doi: 10.1038/s41598-017-04305-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Transduction of P301L hTau in MEC for one month induced hippocampus-dependent memory deficits with an intact olfactory function. (A) In odor cross-habituation test, the olfactory function was intact in both groups revealed by cross-habituation index. (B) The STFP test showed that the olfactory-dependent memory was attenuate significantly in P301L hTau transduced mice compared to control. (C) In the MWM test, escape latency of training indicated that learning capacity of P301L hTau transduced mice kept normal like control mice. (D) The probe test showed that the expression of P301L hTau in MEC impaired hippocampal-dependent spatial memory of mice. (vector, n = 8, P301L, n = 11. *p < 0.05). Data were expressed as mean ± SD.