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. 2017 Jun 20;7:3914. doi: 10.1038/s41598-017-04305-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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P301L hTau transduction in MEC decreases the probability of presynaptic transmitter release. (A) Microdialysis results indicated the lactate level was significantly reduced. (B,C) The levels of dopamine and 5-HIAA (monoamine neurotransmitter or the metabolites) were also decreased in the intercellular space, while the levels of Ala, Hva, Gly, Glu and GABA were not changed (D–H). (n = 6 per group, *p < 0.05). (I) Input-output curve of the EC-DG perforant path fibers. (J) Mutant P301L hTau produced a decrease of PPF in PP-DG pathway (n = 3 per group, 9 slices, **p < 0.01). Data were expressed as mean ± SEM.