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. 2017 Jun 20;7:3914. doi: 10.1038/s41598-017-04305-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Expression of P301L hTau in MEC inhibits synaptic plasticity of PP-DG. (A) The Long-term potentiation of PP-DG was inhibited in P301L hTau transduced mice. The inset graphs represent for each group an example of unit fEPSP before (dark line) and after (light line) LTP induction, which revealed that LTP induction is reduced in P301L hTau transduced mice (HFS, high frequency stimulation. n = 3 per group, 9 slices **p < 0.01). (B) Golgi-stain revealed that the MEC spine density was decreased in MEC and DG of P301L hTau transduced mice. (C) Quantitative analysis of spine density. (n = 3 per group, 9 slices, **p < 0.01. Scale bar, 10 μm). (D,E) Levels of synaptophysin and synaptotagmin I (presynaptic proteins) and NMDAR1 and PSD95 (postsynaptic proteins) were decreased in both the hippocampus and cortex of P301L hTau transduced mice (n = 3 per group, *p < 0.05). Cropped blots are displayed here and full-length blots are included in the Supplementary Information. Data were expressed as mean ± SEM.