Figure 6.

Observed metabolic pathways and fluxes in (A) Fth Beaver/Fth LVS, and (B) Fno from exogenous glucose (red arrows), serine (green arrows), and glycerol (blue arrows). (C) Differences in the metabolic fluxes between Fth and Fno (Fth–Fno). Metabolites studied by GC-MS-based isotopolog profiling are indicated by black boxes. The numbers indicate normalized overall ¹³C-enrichments (from labeled glucose, glycerol and serine in red, blue and green, respectively). The arrow widths roughly indicate the relative fluxes. Fluxes conducive to enrichments <1% are not shown. In (C) the numbers indicate the differences in the normalized overall ¹³C-enrichments (Fth–Fno). Higher fluxes in Fth are indicated by normal arrows, lower fluxes by dashed arrows.