Fig. 4.

Suppression of EAE upon adoptive transfer of peptide-specific T cell lines. Peptide-specific T cells (5 × 10⁶) from lines established after immunization with J2, J3, or J5 alone were transferred into naïve SJL/J mice, and then, on the next day, the mice were immunized s.c. with 50 μg of PLP 139–151 in CFA. Appearance of clinical signs of EAE was monitored daily and the disease severity was scored. P values vs. control on day 22 (n = 9 per group): J2, <0.0005; J3, <0.0003; J5, <0.0001. Experiment performed twice.