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. 2017 Jun 21;7:274. doi: 10.3389/fcimb.2017.00274

Figure 1.

Figure 1

Lung transcript levels of key cytokines in response to intratracheal instillation in rats of sterile agar beads or P. aeruginosa-loaded beads (A). Lung transcript levels of main proinflammatory cytokines Ifnγ, Tnfα, IL-1β, and IL-12a for sterile beads (St-bead) and for P. aeruginosa beads (Pa-bead) at post-infection time-points day (d)1 (white columns) and d3 (gray columns), compared to control animals (No bead). The most drastic elevation for these cytokines was noted for Pa-bead group at d1. (B) Similarly, Th17 cytokine analysis of IL-17a, IL-17f, IL22, IL23a showed highest lung expression levels in Pa-bead group at d1 post-infection. (C) Increased expression of Th2 cytokines IL-5 and IL-13 was noted for St-bead group at both d1 and d3 time-points. (D) Highest lung expression levels of immunomodulatory cytokines IL-6 and IL-10 for Pa-bead group at d1. (A–D), *P < 0.05; **P < 0.01; ***P < 0.001; asterisk above the vertical bars denotes significance against No bead control group; n = 6 animals per group.