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. 2017 Jun 21;8:365. doi: 10.3389/fphar.2017.00365

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Copyright © 2017 Sidorova, Bespalov, Wong, Kambur, Jokinen, Lilius, Suleymanova, Karelson, Rauhala, Karelson, Osborne, Keast, Kalso and Saarma.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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BT13 does not signal in the absence of RET. BT13 does not increase luciferase activity in reporter gene-based assay in cells expressing TrkA (A) and TrkB (B). BT13 does not stimulate TrkA (C) and TrkB (D) phosphorylation. BT13 does not promote activation of intracellular signaling cascades in cells expressing TrkA (E), TrkB (F) or parental cells lacking receptors for neurotrophic factors (G). IP, immunoprecipitation; G, GDNF; pY, phosphotyrosine; pAkt, phosphorylated form of Akt; pErk, phosphorylated forms of Erk1/2; GAPDH, glyceraldehyde 3-phosphate dehydrogenase, loading control.