FIGURE 2.

Effects of oral administration and intraperitoneal inoculation of L. helveticus SBT2171 on arthritis incidence and body weight loss. CIA was induced in DBA/1J mice by immunization with bovine type II collagen twice, on days 0 and 21. Mice were given L. helveticus SBT2171 or vehicle control orally (per os; p.o.) (left) or intraperitoneally (i.p.) (right). Arthritis incidence (A) and changes in body weight (B) were monitored after the second immunization. Data are presented as the mean ± SEM (n = 8–12). The data of the group given L. helveticus SBT2171 were compared to those of the control group by a log-rank test (A) or two-way repeated-measures analysis of variance (group × time interaction) (B).