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Effects of L. helveticus SBT2171 on the serum level of CII-specific IgG and total IgG. The level of antibodies in the serum of CIA mice given L. helveticus SBT2171 orally (p.o.) (A) or intraperitoneally (i.p.) (B) was measured at day 42. Data are presented as dot plots (n = 8–12); center line, median; box, 25th–75th percentile of the data; error bars, 10th–90th percentile of the data. ∗P < 0.05, ∗∗P < 0.01, compared to the control by the Mann–Whitney U-test.
