Table 3. No Correlation between NUDT15 Genotypes and the Incidence of GI Intolerance to Azathioprine.
| Gene | NUDT15 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Coding SNP (location) | p.Val18_Val19insGlyVal (exon 1) | p.Val18Ile (exon 1) | p.Arg139Cys (exon 3) | |||||||
| Type of variants | 6-bp insertion | P-value | Missense | P-value | Missense | P-value | ||||
| Genotype | -/- | -/GGAGTC | G/G | G/A | C/C | C/T | T/T | |||
| No. of patients | 116 (94.3) | 7 (5.7) | 121 (98.4) | 2 (1.6) | 93 (75.6) | 22 (17.9) | 8 (6.5) | |||
| Male/female | 66/50 | 6/1 | 71/50 | 1/1 | 54/39 | 13/9 | 5/3 | |||
| No GI intolerance | 107 (94.7) | 6 (5.3) | 111 (98.2) | 2 (1.8) | 86 (76.1) | 20 (17.7) | 7 (6.2) | |||
| GI intolerance | 9 (90.0) | 1 (10.0) | 0.4562 | 10 (100.0) | 0 | - | 7 (70.0) | 2 (20.0) | 1 (10.0) | 0.8706 |
Values are presented as number (%).
GI, gastrointestinal; SNP, single nucleotide polymorphism.