Table 1.
The median lethal dose (LD50) values of barberry and berberine
| Compound | Animals | Route of administration | LD50 value | Ref. |
|---|---|---|---|---|
| B. vulgaris (powdered root) | Mice | Oral | 2600 mg/kg | (28) |
| B. vulgaris (root extract fraction) | Rat | Oral | 1280 mg/kg | (29) |
| Mice | 520 mg/kg | |||
| Berberine | Mice | IP | 23 mg/kg | (29) |
| Mice | Oral | 329 mg/kg | (30) | |
| Berberine (rhizoma coptidis) | Mice | Oral | 713.58 mg/kg | (35,36) |
| Berberine sulphate | Rat | Oral | > 1 g/kg | (29) |
| Berberine sulphate (Berberis aristata) | Rat | IP | 205 mg/kg | (31) |
| Berberine sulphate | Rat | Oral | 1000 mg/kg | (32) |
| Mice | 329 mg/kg | |||
| Berberine hydrochloride | Mice | IV | 9.0386 mg/kg | (34) |
| IP | 57.6103 mg/kg | |||
| Rhizoma coptidis | Mice | Oral | 4890 mg/kg | (37) |
| Rhizoma coptidis (fibrous root) | Mice | Oral | > 7000 mg/kg |