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. 2017 May;20(5):516–529. doi: 10.22038/IJBMS.2017.8676

Table 1.

The median lethal dose (LD50) values of barberry and berberine

Compound Animals Route of administration LD50 value Ref.
B. vulgaris (powdered root) Mice Oral 2600 mg/kg (28)
B. vulgaris (root extract fraction) Rat Oral 1280 mg/kg (29)
Mice 520 mg/kg
Berberine Mice IP 23 mg/kg (29)
Mice Oral 329 mg/kg (30)
Berberine (rhizoma coptidis) Mice Oral 713.58 mg/kg (35,36)
Berberine sulphate Rat Oral > 1 g/kg (29)
Berberine sulphate (Berberis aristata) Rat IP 205 mg/kg (31)
Berberine sulphate Rat Oral 1000 mg/kg (32)
Mice 329 mg/kg
Berberine hydrochloride Mice IV 9.0386 mg/kg (34)
IP 57.6103 mg/kg
Rhizoma coptidis Mice Oral 4890 mg/kg (37)
Rhizoma coptidis (fibrous root) Mice Oral > 7000 mg/kg