Table 3.

The effect of Berberis vulgaris or berberine on cancer cell line under in vivo conditions

Type	Dose	Toxic responses	Ref.
SiHa treated	Berberine 20 mg/kg	Reduced angiogenesis, tumor growth properties and pulmonary colonization of SiHa cells	(59)
Azoxymethane initiated and dextran sulfate sodium promoted colorectal carcinogenesis	Berberine: 40 mg/kg, orally, mice, for 10 weeks	Berberine reduced tumor multiplicity compare with control group and significantly decreased COX-2 synthesis	(66)
Prostate cancer PC-3 and LNCaP cells	Berberine: 5, 10 mg/kg, IP, for 4 weeks twice per week	Tumor size and growth was decresed	(67)
DLA cells to induce ascites tumour and solid tumour, separately	Berberine hydrochloride (10, 2.5 and 0.5 mg/kg/day), IP for 10 days	Increased life span and reduced tumore size	(68)
	Berberine hydrochloride (25, 5 and 1 mg/kg), orally for 10 days
LLC	Berberine: 1, 2 mg/kg, IP	Berberine with infrared radiation significantly decreased tumor volume Berberine treatment alone has promising effects on suppressing tumor growth	(69)
4T1 treated	Berberine chloride n-hydrate: 100 mg/kg/day, Orally, one month	Moderately inhibited tumor growth in 4T1 cells	(73)
Murine sarcoma S180	Berberine 30 mg/kg, IV	Decreased tumor weight	(74)