Figure 4.

Effect of berberine on intracellular glutathione (GSH) content of glutamate-injured N2a and PC12 cells. The cells were pre-treated (2 hr) with various concentrations of berberine and then exposed to glutamate (10 mM) for 24 hr, in which the same treatments were applied. The data were expressed as means±SEM from three independent experiments. ^#P<0.05, ^###P<0.001 as compared to untreated N2a cells cultured in glutamate condition. *P<0.05, ***P<0.001 as compared to untreated PC12 cells cultured in glutamate condition